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About Me
Postdoctoral researcher at the University of Oxford studying how the brain’s neuromodulatory systems shape cognition, consciousness, and disease.
Posts
A Beginner’s Guide to REACT Analysis: Bridging the Gap from Neurotransmitters to Networks in fMRI
Published:
Functional MRI (fMRI) has revolutionized cognitive neuroscience, allowing us to map neural activity and connectivity non-invasively. However, fMRI has a fundamental limitation: the BOLD signal is blind to the cellular and molecular mechanisms that give rise to it (see [1] for review). When we see altered connectivity in a patient or after administering a drug, we’re left asking: which neurotransmitter systems are giving rise to this?
How can a story of childhood abuse, an almond-shaped bit of brain, and mass-murder shed light on our intuitions of free will?
Published:
Are you free to do as you please? When you saw this blog post, did you choose to read it? Clearly you have clicked the link, but do you have a strong set of arguments as to why you did so? For most people, the decision to click the link will have been made largely subconsciously. “Huh, that might be interesting” is likely as far as you got. What about why it is interesting? Why is this more interesting than the other things you chose not to read today? Or less interesting than the thing you will choose to read instead when you give up a blog post so full of annoying rhetorical questions?
Evolved Discontent
Published:
Disclaimer: these are the written extension of a rambling series of conversations (which may or may not have happened alongside some yeasty beverages). As such, this is not well researched nor integrated into broader theories of evolutionary psychology.
Something weighing heavy on your mind? Measuring thoughts with a set of scales
Published:
Today, neuroscientists generally agree that mental processes are intimately associated with the function of the brain. However, this hasn’t always been the case. For example, Descartes’ famous distinction between res cogitans, the stuff of thought, and res extensa, the stuff of matter has persisted strongly over the 350+ years since his death. So what evidence has led to our modern understanding of the mind and brain? This is the brief story of the man who used a glorified kitchen scale to measure thoughts well over a hundred years ago in the first ever neuroimaging study.
What can giving MDMA to octopi teach us about human social behaviour?
Published:
Despite the human and octopus lineages being separated by 500 million years of evolution, we still share some similarities in the ancient neurotransmitter systems that form a key part of the way our brains work. In this time octopi developed several extra legs and humans went on to dominate the globe using just two, and on the way, we discovered several substances which can profoundly alter our brains’ neurochemistry.
portfolio
publications
Cerebellar correlates of visual hallucinations in Parkinson’s disease and Charles Bonnet Syndrome
Cortex, 2021
Lawn, T., & ffytche, D. (2021). Cerebellar correlates of visual hallucinations in Parkinson's disease and Charles Bonnet Syndrome. Cortex, 135, 311-325.
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Pain in the neurodegenerating brain: insights into pharmacotherapy for Alzheimer disease and Parkinson disease
Pain, 2021
Lawn, T., Aman, Y., Rukavina, K., Sideris-Lampretsas, G., Howard, M., Ballard, C., Chaudhuri, K.R., & Malcangio, M. (2021). Pain in the neurodegenerating brain: insights into pharmacotherapy for Alzheimer disease and Parkinson disease. Pain, 162(4), 999-1006.
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Cerebellar involvement in hallucinations may transcend clinical conditions and perceptual modalities
Cortex, 2021
Lawn, T., & ffytche, D. (2021). Cerebellar involvement in hallucinations may transcend clinical conditions and perceptual modalities. Cortex.
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Response to Mylius et al.
Pain, 2022
Lawn, T., Rukavina, K., Malcangio, M., Howard, M., & Chaudhuri, K.R. (2022). Response to Mylius et al. Pain, 163(3), e496-e497.
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Differential contributions of serotonergic and dopaminergic functional connectivity to the phenomenology of LSD
Psychopharmacology, 2022
Lawn, T., Dipasquale, O., Vamvakas, A., et al. (2022). Differential contributions of serotonergic and dopaminergic functional connectivity to the phenomenology of LSD. Psychopharmacology.
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Neurotransmitter receptor densities are associated with changes in regional Cerebral blood flow during clinical ongoing pain
Human Brain Mapping, 2022
Vamvakas, A., Lawn, T., Veronese, M., Williams, S.C.R., Tsougos, I., & Howard, M.A. (2022). Neurotransmitter receptor densities are associated with changes in regional Cerebral blood flow during clinical ongoing pain. Human Brain Mapping, 43(17), 5235-5249.
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The effects of propofol anaesthesia on molecular-enriched networks during resting-state and naturalistic listening
NeuroImage, 2023
Lawn, T., Martins, D., O'Daly, O., Williams, S., Howard, M., & Dipasquale, O. (2023). The effects of propofol anaesthesia on molecular-enriched networks during resting-state and naturalistic listening. NeuroImage, 271, 120018.
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From neurotransmitters to networks: Transcending organizational hierarchies with molecular-informed functional imaging
Neuroscience and Biobehavioral Reviews, 2023
Lawn, T., Howard, M.A., Turkheimer, F., et al. (2023). From neurotransmitters to networks: Transcending organizational hierarchies with molecular-informed functional imaging. Neuroscience and Biobehavioral Reviews.
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Harnessing the power of endogenous pain control mechanisms for novel therapeutics: how might innovations in neuroimaging help?
Current Opinion in Supportive and Palliative Care, 2023
Howard, M.A., Lawn, T., & Kowalczyk, O.S. (2023). Harnessing the power of endogenous pain control mechanisms for novel therapeutics: how might innovations in neuroimaging help? Current Opinion in Supportive and Palliative Care, 17(3), 150-155.
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Beyond biopsychosocial: The keystone mechanism theory of pain
Brain, Behavior, and Immunity, 2023
Lawn, T., Sendel, M., Baron, R., Vollert, J., et al. (2023). Beyond biopsychosocial: The keystone mechanism theory of pain. Brain, Behavior, and Immunity.
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Normative modeling of molecular-based functional circuits captures clinical heterogeneity transdiagnostically in psychiatric patients
Communications Biology, 2024
Lawn, T., Giacomel, A., Martins, D., et al. (2024). Normative modeling of molecular-based functional circuits captures clinical heterogeneity transdiagnostically in psychiatric patients. Communications Biology, 7, 728.
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Improving neuropathic pain treatment–by rigorous stratification from bench to bedside
Journal of Neurochemistry, 2024
Soliman, N., Kersebaum, D., Lawn, T., Sachau, J., Sendel, M., & Vollert, J. (2024). Improving neuropathic pain treatment–by rigorous stratification from bench to bedside. Journal of Neurochemistry, 168(11), 3699-3714.
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Accurate and Interpretable Prediction of Antidepressant Treatment Response from Receptor-informed Neuroimaging
bioRxiv (Preprint), 2025
Tolle, H.M., Luppi, A.I., Lawn, T., Roseman, L., Nutt, D., Carhart-Harris, R.L., & Mediano, P.A.M. (2025). Accurate and Interpretable Prediction of Antidepressant Treatment Response from Receptor-informed Neuroimaging. bioRxiv.
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Cuff Algometry Induces Large Yet Variable Conditioned Pain Modulation Effects
Pain Reports, 2026
Lawn, T., Taylor, J.L., Kowalczyk, O., Graven-Nielsen, T., Howard, M.A., & Bannister, K. (2025). Cuff Algometry Induces Large Yet Variable Conditioned Pain Modulation Effects. Pain Reports.
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Locus Coeruleus Connectivity Confers Cognitive Resilience in Preclinical Alzheimer’s Disease
Under revision at Nature Communications, 2026
Lawn, T., Diez, I., Bueichekú, E., Coughlan, G., Rentz, D. M., Johnson, K. A., Sperling, R. A., Sepulcre, J., & Jacobs, H. I. L. (2026). Locus Coeruleus Connectivity Confers Cognitive Resilience in Preclinical Alzheimer’s Disease. Under revision at Nature Communications.
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Towards Molecular Specificity in Pharmacoimaging
PsyArXiv, 2026
Lawn, T., & Mehta, M.A. (2026). Towards Molecular Specificity in Pharmacoimaging. Imaging Neuroscience. doi:10.1162/IMAG.a.1175
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Spatial collinearity constrains multivariate molecular-enriched network estimation
bioRxiv, 2026
Lawn, T., Nakuci, J., Williams, S.C.R., Turkheimer, F., & Mehta, M.A. (2026). Spatial collinearity constrains multivariate molecular-enriched network estimation. bioRxiv. doi:10.64898/2026.06.10.731385
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Research Priorities for the Neuromodulatory Subcortical Systems (NSS) at the intersection of Sleep-Wake Regulation and Early Alzheimer’s Pathophysiology
Under review at Alzheimer's & Dementia, 2026
Ludwig, M., André, C., Augustinack, J. C., ... Lawn, T., ... Grinberg, L. T., & Jacobs, H. I. L. (2026). Research Priorities for the Neuromodulatory Subcortical Systems (NSS) at the intersection of Sleep-Wake Regulation and Early Alzheimer's Pathophysiology. Under review at Alzheimer's & Dementia.
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